| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | CHI | Robbie Ray* | At | HUC | Corey Kluber | |
| August | 2 | CHI | Tyler Chatwood | At | HUC | Jake Arrieta | |
| August | 3 | CHI | Jeff Samardzija | At | HUC | Jon Lester* | |
| August | 4 | HUC | Hisashi Iwakuma | At | YDR | Marco Estrada | |
| August | 5 | HUC | Carlos Carrasco | At | YDR | Tanner Roark | |
| August | 6 | HUC | Jake Arrieta | At | YDR | Marcus Stroman | |
| August | OFF | ||||||
| August | 7 | + | SYI | Drew Smyly* | At | HUC | Corey Kluber |
| August | 8 | + | SYI | James Paxton* | At | HUC | Jon Lester* |
| August | 9 | + | SYI | Adam Conley* | At | HUC | Hisashi Iwakuma |
| August | 10 | + | SYI | Mike Fiers | At | HUC | Carlos Carrasco |
| August | 11 | + | SYI | Tim Adleman | At | HUC | Corey Kluber |
| August | 12 | + | HUC | Jake Arrieta | At | WRK | Mike Foltynewicz |
| August | 13 | + | HUC | Jon Lester* | At | WRK | Joe Musgrove |
| August | 14 | + | HUC | Hisashi Iwakuma | At | WRK | Kenta Maeda |
| August | 15 | + | HUC | Corey Kluber | At | WRK | Sean Manaea* |
| August | OFF | ||||||
| August | 16 | + | HUC | Jake Arrieta | At | COL | Joe Ross |
| August | 17 | + | HUC | Jon Lester* | At | COL | Matt Wisler |
| August | 18 | + | HUC | Hisashi Iwakuma | At | COL | Steven Wright |
| August | 19 | + | HUC | Corey Kluber | At | COL | Josh Tomlin |
| August | 20 | + | HUC | Carlos Carrasco | At | COL | Ervin Santana |
| August | 21 | + | WRK | Jimmy Nelson | At | HUC | Jake Arrieta |
| August | 22 | + | WRK | Mike Foltynewicz | At | HUC | Jon Lester* |
| August | 23 | + | WRK | Joe Musgrove | At | HUC | Hisashi Iwakuma |
| August | 24 | + | WRK | Kenta Maeda | At | HUC | Corey Kluber |
| + Indicates In Division Game | |||||||