| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Roenis Elias* | At | YDR | Scott Kazmir* | |
| September | 2 | COL | Trevor Bauer | At | YDR | Lance Lynn | |
| September | 3 | COL | T.J. House* | At | YDR | Bud Norris | |
| September | 4 | YDR | Anthony Swarzak | At | DYE | Wily Peralta | |
| September | 5 | YDR | Gerrit Cole | At | DYE | Jesse Chavez | |
| September | 6 | YDR | Scott Kazmir* | At | DYE | Shelby Miller | |
| September | OFF | ||||||
| September | 7 | + | YDR | Lance Lynn | At | NDF | Wei-Ying Chen* |
| September | 8 | + | YDR | Bud Norris | At | NDF | Jacob Degrom |
| September | 9 | + | YDR | Garrett Richards | At | NDF | Jarred Cosart |
| September | 10 | + | YDR | Gerrit Cole | At | NDF | Chris Tillman |
| September | 11 | + | YDR | Scott Kazmir* | At | NDF | Miguel Gonzalez |
| September | 12 | + | HEP | Tom Koehler | At | YDR | Lance Lynn |
| September | 13 | + | HEP | Jason Hammel | At | YDR | Bud Norris |
| September | 14 | + | HEP | Charlie Morton | At | YDR | Garrett Richards |
| September | 15 | + | HEP | Matt Garza | At | YDR | Marcus Stroman |
| September | OFF | ||||||
| September | 16 | YDR | Scott Kazmir* | At | HEN | Rubby De La Rosa | |
| September | 17 | YDR | Lance Lynn | At | HEN | Tyler Skaggs* | |
| September | 18 | YDR | Bud Norris | At | HEN | Nathan Eovaldi | |
| September | 19 | SRD | Gavin Floyd | At | YDR | Gerrit Cole | |
| September | 20 | SRD | Alexander Colome | At | YDR | Garrett Richards | |
| September | 21 | SRD | Jordan Zimmermann | At | YDR | Scott Kazmir* | |
| September | 22 | YDR | Lance Lynn | At | CUB | Dallas Keuchel* | |
| September | 23 | YDR | Bud Norris | At | CUB | Jeremy Guthrie | |
| September | 24 | YDR | Gerrit Cole | At | CUB | Kyle Hendricks | |
| + Indicates In Division Game | |||||||