| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | HEN | Rubby De La Rosa | At | BUR | James Shields | |
| September | 2 | HEN | Tyler Skaggs* | At | BUR | Wade Miley* | |
| September | 3 | HEN | Nathan Eovaldi | At | BUR | Gio Gonzalez* | |
| September | 4 | HEP | Jason Hammel | At | HEN | Kyle Kendrick | |
| September | 5 | HEP | Charlie Morton | At | HEN | C.J. Wilson* | |
| September | 6 | HEP | Matt Garza | At | HEN | Rubby De La Rosa | |
| September | OFF | ||||||
| September | 7 | + | HEN | Tyler Skaggs* | At | TAM | Chris Archer |
| September | 8 | + | HEN | Nathan Eovaldi | At | TAM | Kevin Gausman |
| September | 9 | + | HEN | Kyle Kendrick | At | TAM | Jordan Lyles |
| September | 10 | + | HEN | C.J. Wilson* | At | TAM | Allen Webster |
| September | 11 | + | HEN | Rubby De La Rosa | At | TAM | Brandon McCarthy |
| September | 12 | + | CHI | Matt Cain | At | HEN | Tyler Skaggs* |
| September | 13 | + | CHI | Tim Hudson | At | HEN | Nathan Eovaldi |
| September | 14 | + | CHI | Scott Feldman | At | HEN | Kyle Kendrick |
| September | 15 | + | CHI | Nick Tropeano | At | HEN | Brett Oberholtzer* |
| September | OFF | ||||||
| September | 16 | YDR | Scott Kazmir* | At | HEN | Rubby De La Rosa | |
| September | 17 | YDR | Lance Lynn | At | HEN | Tyler Skaggs* | |
| September | 18 | YDR | Bud Norris | At | HEN | Nathan Eovaldi | |
| September | 19 | CUB | Alfredo Simon | At | HEN | Kyle Kendrick | |
| September | 20 | CUB | Julio Teheran | At | HEN | Brett Oberholtzer* | |
| September | 21 | CUB | Matt Shoemaker | At | HEN | Rubby De La Rosa | |
| September | 22 | HEN | Tyler Skaggs* | At | SRD | Edinson Volquez | |
| September | 23 | HEN | Nathan Eovaldi | At | SRD | Tyler Matzek* | |
| September | 24 | HEN | Kyle Kendrick | At | SRD | Gavin Floyd | |
| + Indicates In Division Game | |||||||