| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DUB | Madison Bumgarner* | At | DET | Vidal Nuno* | |
| September | 2 | DUB | Andrew Cashner | At | DET | Brad Hand* | |
| September | 3 | DUB | Francisco Liriano* | At | DET | Clay Buchholz | |
| September | 4 | DET | Johnny Cueto | At | NDF | Jarred Cosart | |
| September | 5 | DET | Homer Bailey | At | NDF | Chris Tillman | |
| September | 6 | DET | Jered Weaver | At | NDF | Miguel Gonzalez | |
| September | OFF | ||||||
| September | 7 | + | DET | Johnny Cueto | At | CHI | Jeff Samardzija |
| September | 8 | + | DET | Clay Buchholz | At | CHI | Tim Hudson |
| September | 9 | + | DET | Jose D. Fernandez | At | CHI | Scott Feldman |
| September | 10 | + | DET | Rick Porcello | At | CHI | Mark Buehrle* |
| September | 11 | + | DET | Johnny Cueto | At | CHI | Jeff Samardzija |
| September | 12 | + | TAM | Chris Archer | At | DET | Homer Bailey |
| September | 13 | + | TAM | Kevin Gausman | At | DET | Clay Buchholz |
| September | 14 | + | TAM | Jordan Lyles | At | DET | Jose D. Fernandez |
| September | 15 | + | TAM | Allen Webster | At | DET | Johnny Cueto |
| September | OFF | ||||||
| September | 16 | + | DYE | Felix Hernandez | At | DET | Rick Porcello |
| September | 17 | + | DYE | Zack Wheeler | At | DET | Clay Buchholz |
| September | 18 | + | DYE | Jesse Chavez | At | DET | Jose D. Fernandez |
| September | 19 | + | DYE | Shelby Miller | At | DET | Johnny Cueto |
| September | 20 | + | DYE | Wily Peralta | At | DET | Homer Bailey |
| September | 21 | + | DET | Rick Porcello | At | TAM | Allen Webster |
| September | 22 | + | DET | Clay Buchholz | At | TAM | Brandon McCarthy |
| September | 23 | + | DET | Jose D. Fernandez | At | TAM | Chris Archer |
| September | 24 | + | DET | Jered Weaver | At | TAM | Kevin Gausman |
| + Indicates In Division Game | |||||||