| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Roenis Elias* | At | YDR | Scott Kazmir* | |
| September | 2 | COL | Trevor Bauer | At | YDR | Lance Lynn | |
| September | 3 | COL | T.J. House* | At | YDR | Bud Norris | |
| September | 4 | CUB | Dallas Keuchel* | At | COL | Cole Hamels* | |
| September | 5 | CUB | Jeremy Guthrie | At | COL | Tanner Roark | |
| September | 6 | CUB | Alfredo Simon | At | COL | Cliff Lee* | |
| September | OFF | ||||||
| September | 7 | + | CAL | Michael Wacha | At | COL | Chris Young |
| September | 8 | + | CAL | John Danks* | At | COL | Roenis Elias* |
| September | 9 | + | CAL | Ian Kennedy | At | COL | Trevor Bauer |
| September | 10 | + | CAL | Ervin Santana | At | COL | Cole Hamels* |
| September | 11 | + | CAL | Joe Kelly | At | COL | Tanner Roark |
| September | 12 | + | COL | T.J. House* | At | SRD | Edinson Volquez |
| September | 13 | + | COL | Chris Young | At | SRD | Tyler Matzek* |
| September | 14 | + | COL | Roenis Elias* | At | SRD | Alexander Colome |
| September | 15 | + | COL | Cliff Lee* | At | SRD | Gavin Floyd |
| September | OFF | ||||||
| September | 16 | + | HUC | Corey Kluber | At | COL | Trevor Bauer |
| September | 17 | + | HUC | Phil Hughes | At | COL | Cole Hamels* |
| September | 18 | + | HUC | Hisashi Iwakuma | At | COL | Tanner Roark |
| September | 19 | + | HUC | Anibal Sanchez | At | COL | Chris Young |
| September | 20 | + | HUC | Kyle Gibson | At | COL | Roenis Elias* |
| September | 21 | + | COL | Trevor Bauer | At | SYI | Dillon Gee |
| September | 22 | + | COL | Cole Hamels* | At | SYI | Doug Fister |
| September | 23 | + | COL | Tanner Roark | At | SYI | John Lackey |
| September | 24 | + | COL | Chris Young | At | SYI | Henderson Alvarez |
| + Indicates In Division Game | |||||||