| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CRC | Mike Minor* | At | CHI | Nick Tropeano | |
| September | 2 | CRC | Mike Leake | At | CHI | David Buchanan | |
| September | 3 | CRC | Mat Latos | At | CHI | Mark Buehrle* | |
| September | 4 | CHI | Tim Hudson | At | NYY | Yordano Ventura | |
| September | 5 | CHI | Scott Feldman | At | NYY | Dan Haren | |
| September | 6 | CHI | Matt Cain | At | NYY | Yovani Gallardo | |
| September | OFF | ||||||
| September | 7 | + | DET | Johnny Cueto | At | CHI | Jeff Samardzija |
| September | 8 | + | DET | Clay Buchholz | At | CHI | Tim Hudson |
| September | 9 | + | DET | Jose D. Fernandez | At | CHI | Scott Feldman |
| September | 10 | + | DET | Rick Porcello | At | CHI | Mark Buehrle* |
| September | 11 | + | DET | Johnny Cueto | At | CHI | Jeff Samardzija |
| September | 12 | + | CHI | Matt Cain | At | HEN | Tyler Skaggs* |
| September | 13 | + | CHI | Tim Hudson | At | HEN | Nathan Eovaldi |
| September | 14 | + | CHI | Scott Feldman | At | HEN | Kyle Kendrick |
| September | 15 | + | CHI | Nick Tropeano | At | HEN | Brett Oberholtzer* |
| September | OFF | ||||||
| September | 16 | + | TAM | Tyson Ross | At | CHI | Mark Buehrle* |
| September | 17 | + | TAM | Brandon McCarthy | At | CHI | Jeff Samardzija |
| September | 18 | + | TAM | Chris Archer | At | CHI | Tim Hudson |
| September | 19 | + | TAM | Kevin Gausman | At | CHI | Scott Feldman |
| September | 20 | + | TAM | Jordan Lyles | At | CHI | Mark Buehrle* |
| September | 21 | + | CHI | David Buchanan | At | DYE | Felix Hernandez |
| September | 22 | + | CHI | Jeff Samardzija | At | DYE | Zack Wheeler |
| September | 23 | + | CHI | Tim Hudson | At | DYE | Jesse Chavez |
| September | 24 | + | CHI | Scott Feldman | At | DYE | Shelby Miller |
| + Indicates In Division Game | |||||||