| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | NIM | Justin Masterson | At | HUC | Phil Hughes | |
| September | 2 | NIM | Todd Redmond | At | HUC | Derek Holland* | |
| September | 3 | NIM | David Phelps | At | HUC | Brandon Beachy | |
| September | 4 | HUC | James Shields | At | DYE | Bartolo Colon | |
| September | 5 | HUC | Ian Kennedy | At | DYE | Kris Medlen | |
| September | 6 | HUC | Phil Hughes | At | DYE | Felix Hernandez | |
| September | OFF | ||||||
| September | 7 | + | HUC | Derek Holland* | At | COL | Dan Straily |
| September | 8 | + | HUC | James Shields | At | COL | Cole Hamels* |
| September | 9 | + | HUC | Ian Kennedy | At | COL | Jarrod Parker |
| September | 10 | + | HUC | Phil Hughes | At | COL | Jeremy Hefner |
| September | 11 | + | HUC | Brandon Beachy | At | COL | Ricky Nolasco |
| September | 12 | + | SRD | Mark Buehrle* | At | HUC | Derek Holland* |
| September | 13 | + | SRD | Trevor Cahill | At | HUC | James Shields |
| September | 14 | + | SRD | Alexander Cobb | At | HUC | Ian Kennedy |
| September | 15 | + | SRD | Jeremy Hellickson | At | HUC | Phil Hughes |
| September | OFF | ||||||
| September | 16 | + | SYI | Doug Fister | At | HUC | Derek Holland* |
| September | 17 | + | SYI | Yovani Gallardo | At | HUC | James Shields |
| September | 18 | + | SYI | Martin Perez* | At | HUC | Ian Kennedy |
| September | 19 | + | SYI | Travis Wood* | At | HUC | Corey Kluber |
| September | 20 | + | SYI | Henderson Alvarez | At | HUC | Hisashi Iwakuma |
| September | 21 | + | HUC | Derek Holland* | At | SRD | John Danks* |
| September | 22 | + | HUC | Phil Hughes | At | SRD | Mark Buehrle* |
| September | 23 | + | HUC | Ian Kennedy | At | SRD | Trevor Cahill |
| September | 24 | + | HUC | Corey Kluber | At | SRD | Alexander Cobb |
| + Indicates In Division Game | |||||||