| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Ricky Nolasco | At | TAM | Chris Archer | |
| September | 2 | COL | Jeremy Hefner | At | TAM | Jose Quintana* | |
| September | 3 | COL | Cliff Lee* | At | TAM | Alexi Ogando | |
| September | 4 | EGH | Jeff Locke* | At | COL | Cole Hamels* | |
| September | 5 | EGH | Andy Pettitte* | At | COL | Jarrod Parker | |
| September | 6 | EGH | Jonathan Pettibone | At | COL | Ricky Nolasco | |
| September | OFF | ||||||
| September | 7 | + | HUC | Derek Holland* | At | COL | Dan Straily |
| September | 8 | + | HUC | James Shields | At | COL | Cole Hamels* |
| September | 9 | + | HUC | Ian Kennedy | At | COL | Jarrod Parker |
| September | 10 | + | HUC | Phil Hughes | At | COL | Jeremy Hefner |
| September | 11 | + | HUC | Brandon Beachy | At | COL | Ricky Nolasco |
| September | 12 | + | COL | Cliff Lee* | At | CAL | Matt Harvey |
| September | 13 | + | COL | Cole Hamels* | At | CAL | Ervin Santana |
| September | 14 | + | COL | Jarrod Parker | At | CAL | Julio Teheran |
| September | 15 | + | COL | Jeremy Hefner | At | CAL | Wade Davis |
| September | OFF | ||||||
| September | 16 | + | SRD | John Danks* | At | COL | Cliff Lee* |
| September | 17 | + | SRD | Mark Buehrle* | At | COL | Ricky Nolasco |
| September | 18 | + | SRD | Trevor Cahill | At | COL | Cole Hamels* |
| September | 19 | + | SRD | Alexander Cobb | At | COL | Jarrod Parker |
| September | 20 | + | SRD | Jeremy Hellickson | At | COL | Jeremy Hefner |
| September | 21 | + | COL | Cliff Lee* | At | SYI | Doug Fister |
| September | 22 | + | COL | Ricky Nolasco | At | SYI | Yovani Gallardo |
| September | 23 | + | COL | Cole Hamels* | At | SYI | Hyun-Jin Ryu* |
| September | 24 | + | COL | Jarrod Parker | At | SYI | Travis Wood* |
| + Indicates In Division Game | |||||||