| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | SYI | Henderson Alvarez | At | CRC | Josh Johnson | |
| September | 2 | SYI | Clayton Richard* | At | CRC | Stephen Strasburg | |
| September | 3 | SYI | Edinson Volquez | At | CRC | Mat Latos | |
| September | 4 | DYE | Ted Lilly* | At | SYI | Travis Wood* | |
| September | 5 | DYE | Bartolo Colon | At | SYI | Doug Fister | |
| September | 6 | DYE | Felix Hernandez | At | SYI | Henderson Alvarez | |
| September | OFF | ||||||
| September | 7 | GOB | Adam Wainwright | At | SYI | Edinson Volquez | |
| September | 8 | GOB | Felix Doubront* | At | SYI | Travis Wood* | |
| September | 9 | GOB | David Price* | At | SYI | Doug Fister | |
| September | 10 | BUR | Jason Vargas* | At | SYI | Clayton Richard* | |
| September | 11 | BUR | Jon Niese* | At | SYI | Henderson Alvarez | |
| September | 12 | BUR | Gio Gonzalez* | At | SYI | Edinson Volquez | |
| September | 13 | SYI | Travis Wood* | At | NDF | Vance Worley | |
| September | 14 | SYI | Doug Fister | At | NDF | Chris Tillman | |
| September | 15 | SYI | Clayton Richard* | At | NDF | Wei-Yin Chen* | |
| September | OFF | ||||||
| September | 16 | + | SYI | Edinson Volquez | At | HUC | Brandon Beachy |
| September | 17 | + | SYI | Travis Wood* | At | HUC | R.A. Dickey |
| September | 18 | + | SYI | Doug Fister | At | HUC | James Shields |
| September | 19 | + | SYI | Clayton Richard* | At | HUC | Roy Halladay |
| September | 20 | + | SYI | Henderson Alvarez | At | HUC | Brandon Morrow |
| September | 21 | + | COL | Ricky Nolasco | At | SYI | Edinson Volquez |
| September | 22 | + | COL | Madison Bumgarner* | At | SYI | Travis Wood* |
| September | 23 | + | COL | Dan Straily | At | SYI | Doug Fister |
| September | 24 | + | COL | Cliff Lee* | At | SYI | Clayton Richard* |
| + Indicates In Division Game | |||||||