| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DET | Johnny Cueto | At | NIM | David Phelps | |
| September | 2 | DET | Homer Bailey | At | NIM | Justin Masterson | |
| September | 3 | DET | Jered Weaver | At | NIM | Carlos Villanueva | |
| September | 4 | NIM | Zack Greinke | At | DUB | Carlos Zambrano | |
| September | 5 | NIM | Clayton Kershaw* | At | DUB | Cole Hamels* | |
| September | 6 | NIM | Justin Masterson | At | DUB | Chris Capuano* | |
| September | OFF | ||||||
| September | 7 | + | NIM | Zack Greinke | At | DKZ | Jake Peavy |
| September | 8 | + | NIM | Clayton Kershaw* | At | DKZ | Lucas Harrell |
| September | 9 | + | NIM | Justin Masterson | At | DKZ | A.J. Burnett |
| September | 10 | + | NIM | David Phelps | At | DKZ | Jason Hammel |
| September | 11 | + | NIM | Zack Greinke | At | DKZ | Jake Peavy |
| September | 12 | + | YDR | Erik Bedard* | At | NIM | Clayton Kershaw* |
| September | 13 | + | YDR | Max Scherzer | At | NIM | Justin Masterson |
| September | 14 | + | YDR | C.J. Wilson* | At | NIM | Freddy Garcia |
| September | 15 | + | YDR | Dillon Gee | At | NIM | David Phelps |
| September | OFF | ||||||
| September | 16 | + | NDF | Wade Miley* | At | NIM | Justin Masterson |
| September | 17 | + | NDF | Liam Hendriks | At | NIM | Ricky Romero* |
| September | 18 | + | NDF | Vance Worley | At | NIM | Freddy Garcia |
| September | 19 | + | NDF | Chris Tillman | At | NIM | Clayton Kershaw* |
| September | 20 | + | NDF | Wei-Yin Chen* | At | NIM | Justin Masterson |
| September | 21 | + | NIM | David Phelps | At | YDR | Trevor Cahill |
| September | 22 | + | NIM | Zack Greinke | At | YDR | Max Scherzer |
| September | 23 | + | NIM | Freddy Garcia | At | YDR | C.J. Wilson* |
| September | 24 | + | NIM | Justin Masterson | At | YDR | Dillon Gee |
| + Indicates In Division Game | |||||||