| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CVM | Scott Diamond* | At | CAL | Mike Leake | |
| September | 2 | CVM | Ubaldo Jimenez | At | CAL | Matt Moore* | |
| September | 3 | CVM | Barry Zito* | At | CAL | Josh Beckett | |
| September | 4 | CHI | Kevin Millwood | At | CVM | Tommy Hunter | |
| September | 5 | CHI | Jeff Samardzija | At | CVM | J.A. Happ* | |
| September | 6 | CHI | Scott Feldman | At | CVM | Scott Diamond* | |
| September | OFF | ||||||
| September | 7 | + | SRD | Mark Buehrle* | At | CVM | Ubaldo Jimenez |
| September | 8 | + | SRD | Yovani Gallardo | At | CVM | Barry Zito* |
| September | 9 | + | SRD | Jeremy Hellickson | At | CVM | J.A. Happ* |
| September | 10 | + | SRD | Ryan Vogelsong | At | CVM | Scott Diamond* |
| September | 11 | + | SRD | Francisco Liriano* | At | CVM | Tommy Hunter |
| September | 12 | + | CVM | Ubaldo Jimenez | At | HUC | Hisashi Iwakuma |
| September | 13 | + | CVM | Barry Zito* | At | HUC | Ian Kennedy |
| September | 14 | + | CVM | J.A. Happ* | At | HUC | R.A. Dickey |
| September | 15 | + | CVM | Scott Diamond* | At | HUC | Roy Halladay |
| September | OFF | ||||||
| September | 16 | + | CVM | Ubaldo Jimenez | At | COL | Ricky Nolasco |
| September | 17 | + | CVM | Barry Zito* | At | COL | Madison Bumgarner* |
| September | 18 | + | CVM | Tommy Hunter | At | COL | Dan Straily |
| September | 19 | + | CVM | Scott Diamond* | At | COL | Cliff Lee* |
| September | 20 | + | CVM | J.A. Happ* | At | COL | Chad Billingsley |
| September | 21 | + | HUC | R.A. Dickey | At | CVM | Ubaldo Jimenez |
| September | 22 | + | HUC | James Shields | At | CVM | Barry Zito* |
| September | 23 | + | HUC | Ian Kennedy | At | CVM | Tommy Hunter |
| September | 24 | + | HUC | Roy Halladay | At | CVM | Scott Diamond* |
| + Indicates In Division Game | |||||||