| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Ricky Nolasco | At | VRN | Joe Blanton | |
| September | 2 | COL | Madison Bumgarner* | At | VRN | Bronson Arroyo | |
| September | 3 | COL | Chad Billingsley | At | VRN | Luke Hochevar | |
| September | 4 | EGH | Matt Harrison* | At | COL | Cole Devries | |
| September | 5 | EGH | Tommy Milone* | At | COL | Cliff Lee* | |
| September | 6 | EGH | Nathan Eovaldi | At | COL | Ricky Nolasco | |
| September | OFF | ||||||
| September | 7 | + | HUC | Hisashi Iwakuma | At | COL | Madison Bumgarner* |
| September | 8 | + | HUC | Ian Kennedy | At | COL | Cole Devries |
| September | 9 | + | HUC | R.A. Dickey | At | COL | Cliff Lee* |
| September | 10 | + | HUC | Roy Halladay | At | COL | Chad Billingsley |
| September | 11 | + | HUC | James Shields | At | COL | Ricky Nolasco |
| September | 12 | + | COL | Madison Bumgarner* | At | SRD | Mark Buehrle* |
| September | 13 | + | COL | Dan Straily | At | SRD | Mark Rogers |
| September | 14 | + | COL | Cliff Lee* | At | SRD | Jeremy Hellickson |
| September | 15 | + | COL | Chad Billingsley | At | SRD | Paul Maholm* |
| September | OFF | ||||||
| September | 16 | + | CVM | Ubaldo Jimenez | At | COL | Ricky Nolasco |
| September | 17 | + | CVM | Barry Zito* | At | COL | Madison Bumgarner* |
| September | 18 | + | CVM | Tommy Hunter | At | COL | Dan Straily |
| September | 19 | + | CVM | Scott Diamond* | At | COL | Cliff Lee* |
| September | 20 | + | CVM | J.A. Happ* | At | COL | Chad Billingsley |
| September | 21 | + | COL | Ricky Nolasco | At | SYI | Edinson Volquez |
| September | 22 | + | COL | Madison Bumgarner* | At | SYI | Travis Wood* |
| September | 23 | + | COL | Dan Straily | At | SYI | Doug Fister |
| September | 24 | + | COL | Cliff Lee* | At | SYI | Clayton Richard* |
| + Indicates In Division Game | |||||||