| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | YDR | Chris Young | At | CHI | Anthony Bass | |
| September | 2 | YDR | Trevor Cahill | At | CHI | Tim Hudson | |
| September | 3 | YDR | Erik Bedard* | At | CHI | Matt Cain | |
| September | 4 | CHI | Kevin Millwood | At | CVM | Tommy Hunter | |
| September | 5 | CHI | Jeff Samardzija | At | CVM | J.A. Happ* | |
| September | 6 | CHI | Scott Feldman | At | CVM | Scott Diamond* | |
| September | OFF | ||||||
| September | 7 | + | CHI | Tim Hudson | At | DYE | Patrick Corbin* |
| September | 8 | + | CHI | Matt Cain | At | DYE | Jeff Karstens |
| September | 9 | + | CHI | Kevin Millwood | At | DYE | Felix Hernandez |
| September | 10 | + | CHI | Jeff Samardzija | At | DYE | Bartolo Colon |
| September | 11 | + | CHI | Scott Feldman | At | DYE | Kris Medlen |
| September | 12 | + | DET | Johnny Cueto | At | CHI | Tim Hudson |
| September | 13 | + | DET | Jaime Garcia* | At | CHI | Matt Cain |
| September | 14 | + | DET | Mike Fiers | At | CHI | Kevin Millwood |
| September | 15 | + | DET | Wandy Rodriguez* | At | CHI | Jeff Samardzija |
| September | OFF | ||||||
| September | 16 | + | GOB | Dan Haren | At | CHI | Tim Hudson |
| September | 17 | + | GOB | David Price* | At | CHI | Matt Cain |
| September | 18 | + | GOB | Edwin Jackson | At | CHI | Kevin Millwood |
| September | 19 | + | GOB | Felix Doubront* | At | CHI | Jeff Samardzija |
| September | 20 | + | GOB | Adam Wainwright | At | CHI | Scott Feldman |
| September | 21 | + | CHI | Tim Hudson | At | DET | Jaime Garcia* |
| September | 22 | + | CHI | Matt Cain | At | DET | Johnny Cueto |
| September | 23 | + | CHI | Kevin Millwood | At | DET | Wandy Rodriguez* |
| September | 24 | + | CHI | Jeff Samardzija | At | DET | Mike Fiers |
| + Indicates In Division Game | |||||||