| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CVM | C.C. Sabathia* | At | YDR | Kyle Lohse | |
| September | 2 | CVM | Chris Carpenter | At | YDR | Bruce Chen* | |
| September | 3 | CVM | Brandon Morrow | At | YDR | Justin Verlander | |
| September | 4 | YDR | Trevor Cahill | At | EGH | Joe Saunders* | |
| September | 5 | YDR | Erik Bedard* | At | EGH | Fausto Carmona | |
| September | 6 | YDR | Kyle Kendrick | At | EGH | Matt Harrison* | |
| September | OFF | ||||||
| September | 7 | + | NIM | Clayton Kershaw* | At | YDR | Justin Verlander |
| September | 8 | + | NIM | Scott Baker | At | YDR | Kyle Lohse |
| September | 9 | + | NIM | Justin Masterson | At | YDR | Trevor Cahill |
| September | 10 | + | NIM | Zack Greinke | At | YDR | Erik Bedard* |
| September | 11 | + | NIM | Clayton Kershaw* | At | YDR | Justin Verlander |
| September | 12 | + | YDR | Bruce Chen* | At | NDF | John Danks* |
| September | 13 | + | YDR | Kyle Lohse | At | NDF | Mark Buehrle* |
| September | 14 | + | YDR | Trevor Cahill | At | NDF | Vance Worley |
| September | 15 | + | YDR | Kyle Kendrick | At | NDF | Kyle McClellan |
| September | OFF | ||||||
| September | 16 | + | DKZ | A.J. Burnett | At | YDR | Justin Verlander |
| September | 17 | + | DKZ | Derek Lowe | At | YDR | Kyle Lohse |
| September | 18 | + | DKZ | James McDonald | At | YDR | Trevor Cahill |
| September | 19 | + | DKZ | Mike Pelfrey | At | YDR | Kyle Kendrick |
| September | 20 | + | DKZ | Bronson Arroyo | At | YDR | Justin Verlander |
| September | 21 | + | YDR | Bruce Chen* | At | TAM | Alexi Ogando |
| September | 22 | + | YDR | Dillon Gee | At | TAM | Ted Lilly* |
| September | 23 | + | YDR | Trevor Cahill | At | TAM | Ryan Dempster |
| September | 24 | + | YDR | Brett Cecil* | At | TAM | Tim Stauffer |
| + Indicates In Division Game | |||||||