| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | SSB | Henderson Alvarez | At | NDF | Mark Buehrle* | |
| September | 2 | SSB | Clayton Richard* | At | NDF | John Danks* | |
| September | 3 | SSB | Brett Myers | At | NDF | Vance Worley | |
| September | 4 | CAL | Dustin Moseley | At | SSB | Kevin Correia | |
| September | 5 | CAL | Brett Anderson* | At | SSB | Jeremy Guthrie | |
| September | 6 | CAL | Mike Leake | At | SSB | Doug Fister | |
| September | OFF | ||||||
| September | 7 | + | HUC | R.A. Dickey | At | SSB | Brett Myers |
| September | 8 | + | HUC | James Shields | At | SSB | Kevin Correia |
| September | 9 | + | HUC | Roy Halladay | At | SSB | Clayton Richard* |
| September | 10 | + | HUC | Ian Kennedy | At | SSB | Jeremy Guthrie |
| September | 11 | + | HUC | Brandon Beachy | At | SSB | Brett Myers |
| September | 12 | + | SSB | Henderson Alvarez | At | SRD | Paul Maholm* |
| September | 13 | + | SSB | Kevin Correia | At | SRD | Alex Cobb |
| September | 14 | + | SSB | Doug Fister | At | SRD | Carlos Carrasco |
| September | 15 | + | SSB | Brett Myers | At | SRD | Daisuke Matsuzaka |
| September | OFF | ||||||
| September | 16 | + | COL | Ricky Romero* | At | SSB | Jeremy Guthrie |
| September | 17 | + | COL | Chad Billingsley | At | SSB | Kevin Correia |
| September | 18 | + | COL | Madison Bumgarner* | At | SSB | Brett Myers |
| September | 19 | + | COL | Cliff Lee* | At | SSB | Henderson Alvarez |
| September | 20 | + | COL | Ricky Nolasco | At | SSB | Doug Fister |
| September | 21 | + | SSB | Jeremy Guthrie | At | CVM | Brandon Morrow |
| September | 22 | + | SSB | Brett Myers | At | CVM | C.C. Sabathia* |
| September | 23 | + | SSB | Kevin Correia | At | CVM | Chris Carpenter |
| September | 24 | + | SSB | Henderson Alvarez | At | CVM | Carlos Villanueva |
| + Indicates In Division Game | |||||||