| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | TAM | Alexi Ogando | At | SRD | Jeremy Hellickson | |
| September | 2 | TAM | Tommy Hanson | At | SRD | Paul Maholm* | |
| September | 3 | TAM | Ted Lilly* | At | SRD | Alex Cobb | |
| September | 4 | SRD | Carlos Carrasco | At | VRN | Derek Holland* | |
| September | 5 | SRD | Daisuke Matsuzaka | At | VRN | Gio Gonzalez* | |
| September | 6 | SRD | Jeremy Hellickson | At | VRN | Brian Duensing* | |
| September | OFF | ||||||
| September | 7 | + | SRD | Paul Maholm* | At | COL | Chad Billingsley |
| September | 8 | + | SRD | Alex Cobb | At | COL | Madison Bumgarner* |
| September | 9 | + | SRD | Carlos Carrasco | At | COL | Ricky Romero* |
| September | 10 | + | SRD | Daisuke Matsuzaka | At | COL | Jake Peavy |
| September | 11 | + | SRD | Jeremy Hellickson | At | COL | Cliff Lee* |
| September | 12 | + | SSB | Henderson Alvarez | At | SRD | Paul Maholm* |
| September | 13 | + | SSB | Kevin Correia | At | SRD | Alex Cobb |
| September | 14 | + | SSB | Doug Fister | At | SRD | Carlos Carrasco |
| September | 15 | + | SSB | Brett Myers | At | SRD | Daisuke Matsuzaka |
| September | OFF | ||||||
| September | 16 | SRD | Jeremy Hellickson | At | CAL | Josh Beckett | |
| September | 17 | SRD | Paul Maholm* | At | CAL | Dustin Moseley | |
| September | 18 | SRD | Alex Cobb | At | CAL | Daniel Hudson | |
| September | 19 | SRD | Carlos Carrasco | At | NDF | Vance Worley | |
| September | 20 | SRD | Edinson Volquez | At | NDF | Kyle McClellan | |
| September | 21 | SRD | Jeremy Hellickson | At | NDF | Luke Hochevar | |
| September | 22 | EGH | Jake Westbrook | At | SRD | Paul Maholm* | |
| September | 23 | EGH | J.A. Happ* | At | SRD | Alex Cobb | |
| September | 24 | EGH | Joe Saunders* | At | SRD | Carlos Carrasco | |
| + Indicates In Division Game | |||||||