| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | SSB | Henderson Alvarez | At | NDF | Mark Buehrle* | |
| September | 2 | SSB | Clayton Richard* | At | NDF | John Danks* | |
| September | 3 | SSB | Brett Myers | At | NDF | Vance Worley | |
| September | 4 | NDF | Kyle McClellan | At | DET | Jered Weaver | |
| September | 5 | NDF | Mark Buehrle* | At | DET | Rick Porcello | |
| September | 6 | NDF | Luke Hochevar | At | DET | Homer Bailey | |
| September | OFF | ||||||
| September | 7 | + | NDF | John Danks* | At | DKZ | A.J. Burnett |
| September | 8 | + | NDF | Vance Worley | At | DKZ | Bronson Arroyo |
| September | 9 | + | NDF | Mark Buehrle* | At | DKZ | James McDonald |
| September | 10 | + | NDF | Kyle McClellan | At | DKZ | Jason Hammel |
| September | 11 | + | NDF | Luke Hochevar | At | DKZ | Chien-Ming Wang |
| September | 12 | + | YDR | Bruce Chen* | At | NDF | John Danks* |
| September | 13 | + | YDR | Kyle Lohse | At | NDF | Mark Buehrle* |
| September | 14 | + | YDR | Trevor Cahill | At | NDF | Vance Worley |
| September | 15 | + | YDR | Kyle Kendrick | At | NDF | Kyle McClellan |
| September | OFF | ||||||
| September | 16 | NDF | Luke Hochevar | At | EGH | Matt Harrison* | |
| September | 17 | NDF | John Danks* | At | EGH | Danny Duffy* | |
| September | 18 | NDF | Mark Buehrle* | At | EGH | J.A. Happ* | |
| September | 19 | SRD | Carlos Carrasco | At | NDF | Vance Worley | |
| September | 20 | SRD | Edinson Volquez | At | NDF | Kyle McClellan | |
| September | 21 | SRD | Jeremy Hellickson | At | NDF | Luke Hochevar | |
| September | 22 | NDF | John Danks* | At | CAL | Mike Leake | |
| September | 23 | NDF | Mark Buehrle* | At | CAL | Daniel Hudson | |
| September | 24 | NDF | Michael Pineda | At | CAL | Jordan Zimmermann | |
| + Indicates In Division Game | |||||||