| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | VRN | Brian Duensing* | At | DYE | Randy Wells | |
| September | 2 | VRN | Jonathan Sanchez* | At | DYE | Jeff Karstens | |
| September | 3 | VRN | Ervin Santana | At | DYE | Gavin Floyd | |
| September | 4 | DYE | Felix Hernandez | At | TAM | Brandon McCarthy | |
| September | 5 | DYE | Chris Volstad | At | TAM | Ryan Dempster | |
| September | 6 | DYE | Randy Wells | At | TAM | Alexi Ogando | |
| September | OFF | ||||||
| September | 7 | + | GOB | Ivan Nova | At | DYE | Gavin Floyd |
| September | 8 | + | GOB | Dan Haren | At | DYE | Felix Hernandez |
| September | 9 | + | GOB | Philip Humber | At | DYE | Chris Volstad |
| September | 10 | + | GOB | Edwin Jackson | At | DYE | Randy Wells |
| September | 11 | + | GOB | Wade Davis | At | DYE | Jeff Karstens |
| September | 12 | + | DYE | Gavin Floyd | At | EGH | Jake Westbrook |
| September | 13 | + | DYE | Felix Hernandez | At | EGH | J.A. Happ* |
| September | 14 | + | DYE | Chris Volstad | At | EGH | Joe Saunders* |
| September | 15 | + | DYE | Randy Wells | At | EGH | Fausto Carmona |
| September | OFF | ||||||
| September | 16 | + | CHI | Ryan Vogelsong | At | DYE | Jeff Karstens |
| September | 17 | + | CHI | Matt Cain | At | DYE | Felix Hernandez |
| September | 18 | + | CHI | Tim Hudson | At | DYE | Chris Volstad |
| September | 19 | + | CHI | Jair Jurrjens | At | DYE | Randy Wells |
| September | 20 | + | CHI | Jhoulys Chacin | At | DYE | Gavin Floyd |
| September | 21 | + | DYE | Phil Hughes | At | DET | Clay Buchholz |
| September | 22 | + | DYE | Felix Hernandez | At | DET | Rick Porcello |
| September | 23 | + | DYE | Chris Volstad | At | DET | Johnny Cueto |
| September | 24 | + | DYE | Jeff Karstens | At | DET | Jered Weaver |
| + Indicates In Division Game | |||||||