| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DKZ | Mike Pelfrey | At | HUC | Ian Kennedy | |
| September | 2 | DKZ | Jason Hammel | At | HUC | R.A. Dickey | |
| September | 3 | DKZ | A.J. Burnett | At | HUC | James Shields | |
| September | 4 | GOB | Philip Humber | At | DKZ | Derek Lowe | |
| September | 5 | GOB | Edwin Jackson | At | DKZ | James McDonald | |
| September | 6 | GOB | Wade Davis | At | DKZ | Mike Pelfrey | |
| September | OFF | ||||||
| September | 7 | + | NDF | John Danks* | At | DKZ | A.J. Burnett |
| September | 8 | + | NDF | Vance Worley | At | DKZ | Bronson Arroyo |
| September | 9 | + | NDF | Mark Buehrle* | At | DKZ | James McDonald |
| September | 10 | + | NDF | Kyle McClellan | At | DKZ | Jason Hammel |
| September | 11 | + | NDF | Luke Hochevar | At | DKZ | Chien-Ming Wang |
| September | 12 | + | DKZ | A.J. Burnett | At | NIM | Roy Oswalt |
| September | 13 | + | DKZ | Derek Lowe | At | NIM | Justin Masterson |
| September | 14 | + | DKZ | James McDonald | At | NIM | Ubaldo Jimenez |
| September | 15 | + | DKZ | Mike Pelfrey | At | NIM | Zack Greinke |
| September | OFF | ||||||
| September | 16 | + | DKZ | A.J. Burnett | At | YDR | Justin Verlander |
| September | 17 | + | DKZ | Derek Lowe | At | YDR | Kyle Lohse |
| September | 18 | + | DKZ | James McDonald | At | YDR | Trevor Cahill |
| September | 19 | + | DKZ | Mike Pelfrey | At | YDR | Kyle Kendrick |
| September | 20 | + | DKZ | Bronson Arroyo | At | YDR | Justin Verlander |
| September | 21 | + | NIM | Zack Greinke | At | DKZ | A.J. Burnett |
| September | 22 | + | NIM | Justin Masterson | At | DKZ | Derek Lowe |
| September | 23 | + | NIM | Ubaldo Jimenez | At | DKZ | James McDonald |
| September | 24 | + | NIM | Juan Nicasio | At | DKZ | Mike Pelfrey |
| + Indicates In Division Game | |||||||