| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DET | Johnny Cueto | At | CAL | Daniel Hudson | |
| September | 2 | DET | Wandy Rodriguez* | At | CAL | Josh Beckett | |
| September | 3 | DET | Jaime Garcia* | At | CAL | Guillermo Moscoso | |
| September | 4 | NDF | Kyle McClellan | At | DET | Jered Weaver | |
| September | 5 | NDF | Mark Buehrle* | At | DET | Rick Porcello | |
| September | 6 | NDF | Luke Hochevar | At | DET | Homer Bailey | |
| September | OFF | ||||||
| September | 7 | DET | Wandy Rodriguez* | At | TAM | Tommy Hanson | |
| September | 8 | DET | Jered Weaver | At | TAM | Ted Lilly* | |
| September | 9 | DET | Jaime Garcia* | At | TAM | Ryan Dempster | |
| September | 10 | DET | Rick Porcello | At | VRN | Brian Duensing* | |
| September | 11 | DET | Homer Bailey | At | VRN | Derek Holland* | |
| September | 12 | DET | Jered Weaver | At | VRN | Gio Gonzalez* | |
| September | 13 | CVM | Brandon Morrow | At | DET | Jaime Garcia* | |
| September | 14 | CVM | Carlos Villanueva | At | DET | Clay Buchholz | |
| September | 15 | CVM | Javier Vazquez | At | DET | Wandy Rodriguez* | |
| September | OFF | ||||||
| September | 16 | + | DET | Jered Weaver | At | GOB | Wade Davis |
| September | 17 | + | DET | Rick Porcello | At | GOB | Ivan Nova |
| September | 18 | + | DET | Johnny Cueto | At | GOB | Dan Haren |
| September | 19 | + | DET | Homer Bailey | At | GOB | Philip Humber |
| September | 20 | + | DET | Jered Weaver | At | GOB | Edwin Jackson |
| September | 21 | + | DYE | Phil Hughes | At | DET | Clay Buchholz |
| September | 22 | + | DYE | Felix Hernandez | At | DET | Rick Porcello |
| September | 23 | + | DYE | Chris Volstad | At | DET | Johnny Cueto |
| September | 24 | + | DYE | Jeff Karstens | At | DET | Jered Weaver |
| + Indicates In Division Game | |||||||