| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CVM | C.C. Sabathia* | At | YDR | Kyle Lohse | |
| September | 2 | CVM | Chris Carpenter | At | YDR | Bruce Chen* | |
| September | 3 | CVM | Brandon Morrow | At | YDR | Justin Verlander | |
| September | 4 | BUR | Randy Wolf* | At | CVM | Javier Vazquez | |
| September | 5 | BUR | Jason Vargas* | At | CVM | C.C. Sabathia* | |
| September | 6 | BUR | Carl Pavano | At | CVM | Sam Lecure | |
| September | OFF | ||||||
| September | 7 | VRN | Derek Holland* | At | CVM | Chris Carpenter | |
| September | 8 | VRN | Jonathan Sanchez* | At | CVM | Brandon Morrow | |
| September | 9 | VRN | Ervin Santana | At | CVM | Carlos Villanueva | |
| September | 10 | TAM | Tim Stauffer | At | CVM | Javier Vazquez | |
| September | 11 | TAM | Alexi Ogando | At | CVM | Sam Lecure | |
| September | 12 | TAM | Tommy Hanson | At | CVM | Alfredo Aceves | |
| September | 13 | CVM | Brandon Morrow | At | DET | Jaime Garcia* | |
| September | 14 | CVM | Carlos Villanueva | At | DET | Clay Buchholz | |
| September | 15 | CVM | Javier Vazquez | At | DET | Wandy Rodriguez* | |
| September | OFF | ||||||
| September | 16 | + | CVM | C.C. Sabathia* | At | HUC | James Shields |
| September | 17 | + | CVM | Sam Lecure | At | HUC | Roy Halladay |
| September | 18 | + | CVM | Chris Carpenter | At | HUC | Ian Kennedy |
| September | 19 | + | CVM | Carlos Villanueva | At | HUC | Brandon Beachy |
| September | 20 | + | CVM | Javier Vazquez | At | HUC | James Shields |
| September | 21 | + | SSB | Jeremy Guthrie | At | CVM | Brandon Morrow |
| September | 22 | + | SSB | Brett Myers | At | CVM | C.C. Sabathia* |
| September | 23 | + | SSB | Kevin Correia | At | CVM | Chris Carpenter |
| September | 24 | + | SSB | Henderson Alvarez | At | CVM | Carlos Villanueva |
| + Indicates In Division Game | |||||||