| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Madison Bumgarner* | At | NIM | Juan Nicasio | |
| September | 2 | COL | Ricky Nolasco | At | NIM | Justin Masterson | |
| September | 3 | COL | Ricky Romero* | At | NIM | Roy Oswalt | |
| September | 4 | DUB | Cole Hamels* | At | COL | Jake Peavy | |
| September | 5 | DUB | Zach Britton* | At | COL | Cliff Lee* | |
| September | 6 | DUB | Colby Lewis | At | COL | Brian Sanches | |
| September | OFF | ||||||
| September | 7 | + | SRD | Paul Maholm* | At | COL | Chad Billingsley |
| September | 8 | + | SRD | Alex Cobb | At | COL | Madison Bumgarner* |
| September | 9 | + | SRD | Carlos Carrasco | At | COL | Ricky Romero* |
| September | 10 | + | SRD | Daisuke Matsuzaka | At | COL | Jake Peavy |
| September | 11 | + | SRD | Jeremy Hellickson | At | COL | Cliff Lee* |
| September | 12 | + | COL | Ricky Nolasco | At | HUC | R.A. Dickey |
| September | 13 | + | COL | Chad Billingsley | At | HUC | Roy Halladay |
| September | 14 | + | COL | Madison Bumgarner* | At | HUC | Ian Kennedy |
| September | 15 | + | COL | Cliff Lee* | At | HUC | Phil Coke* |
| September | OFF | ||||||
| September | 16 | + | COL | Ricky Romero* | At | SSB | Jeremy Guthrie |
| September | 17 | + | COL | Chad Billingsley | At | SSB | Kevin Correia |
| September | 18 | + | COL | Madison Bumgarner* | At | SSB | Brett Myers |
| September | 19 | + | COL | Cliff Lee* | At | SSB | Henderson Alvarez |
| September | 20 | + | COL | Ricky Nolasco | At | SSB | Doug Fister |
| September | 21 | + | HUC | Roy Halladay | At | COL | Ricky Romero* |
| September | 22 | + | HUC | Ian Kennedy | At | COL | Chad Billingsley |
| September | 23 | + | HUC | R.A. Dickey | At | COL | Madison Bumgarner* |
| September | 24 | + | HUC | Phil Coke* | At | COL | Cliff Lee* |
| + Indicates In Division Game | |||||||