| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CHI | Anthony Bass | At | DUB | Colby Lewis | |
| September | 2 | CHI | Matt Cain | At | DUB | C.J. Wilson* | |
| September | 3 | CHI | Tim Hudson | At | DUB | Carlos Zambrano | |
| September | 4 | NIM | Clayton Kershaw* | At | CHI | Jair Jurrjens | |
| September | 5 | NIM | Zack Greinke | At | CHI | Ryan Vogelsong | |
| September | 6 | NIM | Justin Masterson | At | CHI | Matt Cain | |
| September | OFF | ||||||
| September | 7 | + | EGH | Jake Westbrook | At | CHI | Jhoulys Chacin |
| September | 8 | + | EGH | Danny Duffy* | At | CHI | Freddy Garcia |
| September | 9 | + | EGH | Joe Saunders* | At | CHI | Jair Jurrjens |
| September | 10 | + | EGH | Fausto Carmona | At | CHI | Ryan Vogelsong |
| September | 11 | + | EGH | Matt Harrison* | At | CHI | Tim Hudson |
| September | 12 | + | CHI | Matt Cain | At | GOB | Ivan Nova |
| September | 13 | + | CHI | Jhoulys Chacin | At | GOB | Dan Haren |
| September | 14 | + | CHI | Freddy Garcia | At | GOB | Philip Humber |
| September | 15 | + | CHI | Jair Jurrjens | At | GOB | Edwin Jackson |
| September | OFF | ||||||
| September | 16 | + | CHI | Ryan Vogelsong | At | DYE | Jeff Karstens |
| September | 17 | + | CHI | Matt Cain | At | DYE | Felix Hernandez |
| September | 18 | + | CHI | Tim Hudson | At | DYE | Chris Volstad |
| September | 19 | + | CHI | Jair Jurrjens | At | DYE | Randy Wells |
| September | 20 | + | CHI | Jhoulys Chacin | At | DYE | Gavin Floyd |
| September | 21 | + | GOB | Wade Davis | At | CHI | Ryan Vogelsong |
| September | 22 | + | GOB | Dan Haren | At | CHI | Matt Cain |
| September | 23 | + | GOB | David Price* | At | CHI | Tim Hudson |
| September | 24 | + | GOB | Edwin Jackson | At | CHI | Jair Jurrjens |
| + Indicates In Division Game | |||||||