| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | COL | Jorge De La Rosa* | At | CAL | Dustin Moseley | |
| August | 2 | COL | Cliff Lee* | At | CAL | Guillermo Moscoso | |
| August | 3 | COL | Chris Narveson* | At | CAL | Jordan Zimmermann | |
| August | 4 | GOB | Edwin Jackson | At | COL | Josh Tomlin | |
| August | 5 | GOB | Wade Davis | At | COL | Chad Billingsley | |
| August | 6 | GOB | Hiroki Kuroda | At | COL | Brian Sanches | |
| August | OFF | ||||||
| August | 7 | COL | Ricky Romero* | At | CRC | Tim Lincecum | |
| August | 8 | COL | Cliff Lee* | At | CRC | Bud Norris | |
| August | 9 | COL | Jorge De La Rosa* | At | CRC | Shaun Marcum | |
| August | 10 | COL | Brian Sanches | At | DKZ | James McDonald | |
| August | 11 | COL | Josh Tomlin | At | DKZ | Jason Hammel | |
| August | 12 | COL | Chad Billingsley | At | DKZ | A.J. Burnett | |
| August | 13 | CHI | Matt Cain | At | COL | Ricky Romero* | |
| August | 14 | CHI | Jhoulys Chacin | At | COL | Cliff Lee* | |
| August | 15 | CHI | Tim Hudson | At | COL | Jorge De La Rosa* | |
| August | OFF | ||||||
| August | 16 | + | COL | Josh Tomlin | At | SRD | Brian Matusz* |
| August | 17 | + | COL | Ricky Romero* | At | SRD | Carlos Carrasco |
| August | 18 | + | COL | Chad Billingsley | At | SRD | Alfredo Simon |
| August | 19 | + | COL | Cliff Lee* | At | SRD | Lance Lynn |
| August | 20 | + | COL | Brian Sanches | At | SRD | Jeremy Hellickson |
| August | 21 | + | CVM | C.C. Sabathia* | At | COL | Jorge De La Rosa* |
| August | 22 | + | CVM | Brandon Morrow | At | COL | Ricky Romero* |
| August | 23 | + | CVM | Javier Vazquez | At | COL | Chad Billingsley |
| August | 24 | + | CVM | Alfredo Aceves | At | COL | Cliff Lee* |
| + Indicates In Division Game | |||||||