| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | YDR | Justin Verlander | At | CHI | Tim Hudson | |
| August | 2 | YDR | Erik Bedard* | At | CHI | Ryan Vogelsong | |
| August | 3 | YDR | Trevor Cahill | At | CHI | Freddy Garcia | |
| August | 4 | CHI | Matt Cain | At | HUC | R.A. Dickey | |
| August | 5 | CHI | Jhoulys Chacin | At | HUC | James Shields | |
| August | 6 | CHI | Tim Hudson | At | HUC | Roy Halladay | |
| August | OFF | ||||||
| August | 7 | DKZ | A.J. Burnett | At | CHI | Freddy Garcia | |
| August | 8 | DKZ | Chien-Ming Wang | At | CHI | Matt Cain | |
| August | 9 | DKZ | Mike Pelfrey | At | CHI | Jhoulys Chacin | |
| August | 10 | CRC | Mat Latos | At | CHI | Tim Hudson | |
| August | 11 | CRC | Max Scherzer | At | CHI | Ryan Vogelsong | |
| August | 12 | CRC | Tim Lincecum | At | CHI | Freddy Garcia | |
| August | 13 | CHI | Matt Cain | At | COL | Ricky Romero* | |
| August | 14 | CHI | Jhoulys Chacin | At | COL | Cliff Lee* | |
| August | 15 | CHI | Tim Hudson | At | COL | Jorge De La Rosa* | |
| August | OFF | ||||||
| August | 16 | + | CHI | Freddy Garcia | At | EGH | Joe Saunders* |
| August | 17 | + | CHI | Matt Cain | At | EGH | J.A. Happ* |
| August | 18 | + | CHI | Jhoulys Chacin | At | EGH | Fausto Carmona |
| August | 19 | + | CHI | Ryan Vogelsong | At | EGH | Matt Harrison* |
| August | 20 | + | CHI | Tim Hudson | At | EGH | Jake Westbrook |
| August | 21 | + | DET | Wandy Rodriguez* | At | CHI | Freddy Garcia |
| August | 22 | + | DET | Jered Weaver | At | CHI | Matt Cain |
| August | 23 | + | DET | Jaime Garcia* | At | CHI | Jhoulys Chacin |
| August | 24 | + | DET | Rick Porcello | At | CHI | Ryan Vogelsong |
| + Indicates In Division Game | |||||||