| Month | Game | Away | Pitcher | At | Home | Pitcher | |
| September | 1 | CHI | Looper,Braden | At | NDF | Lannan,John* | |
| September | 2 | CHI | Maddux,Greg | At | NDF | Johnson,Randy* | |
| September | 3 | CHI | Mussina,Mike | At | NDF | Nolasco,Ricky | |
| September | 4 | CAL | Zito,Barry* | At | CHI | Cain,Matt | |
| September | 5 | CAL | Jackson,Edwin | At | CHI | Looper,Braden | |
| September | 6 | CAL | Blanton,Joe | At | CHI | Jurrjens,Jair | |
| September | OFF | ||||||
| September | 7 | CHI | Cain,Matt | At | DUB | Wang,Chien-ming | |
| September | 8 | CHI | Looper,Braden | At | DUB | Smoltz,John | |
| September | 9 | CHI | Maddux,Greg | At | DUB | Maholm,Paul* | |
| September | 10 | JEF | Webb,Brandon | At | CHI | Jurrjens,Jair | |
| September | 11 | JEF | Rowland-smith,Ryan* | At | CHI | Cain,Matt | |
| September | 12 | JEF | Kuo,Hong-chih* | At | CHI | Mussina,Mike | |
| September | 13 | CHI | Looper,Braden | At | COL | Lee,Cliff* | |
| September | 14 | CHI | Maddux,Greg | At | COL | Owings,Micah | |
| September | 15 | CHI | Jurrjens,Jair | At | COL | Chamberlain,Joba | |
| September | OFF | ||||||
| September | 16 | + | CHI | Mussina,Mike | At | ACC | Sabathia,C.C.* |
| September | 17 | + | CHI | Looper,Braden | At | ACC | Haren,Dan |
| September | 18 | + | CHI | Maddux,Greg | At | ACC | Greinke,Zack |
| September | 19 | + | CHI | Cain,Matt | At | ACC | Vazquez,Javier |
| September | 20 | + | CHI | Mussina,Mike | At | ACC | Sabathia,C.C.* |
| September | 21 | + | DET | Wolf,Randy* | At | CHI | Looper,Braden |
| September | 22 | + | DET | Cueto,Johnny | At | CHI | Jurrjens,Jair |
| September | 23 | + | DET | Weaver,Jered | At | CHI | Cain,Matt |
| September | 24 | + | DET | Rodriguez,Wandy* | At | CHI | Maddux,Greg |
| + Indicates In Division Game | |||||||